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NO overrelease in vitro) (Sikiric et al., 1997)

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Despite their different location in the nervous system, the fact that they share a major function as myelinating cells probably supports that we could translate to Schwann cells the findings observed for cortistatin in oligodendrocytes, in order to explain their potential involvement in the phenotype observed in the transected nerve of cortistatin-deficient mice and the improvement found after the treatment with cortistatin

However, the full benefits typically develop over 2-3 months of consistent supplementation